Cyclooxygenase-1 Inhibition Prolongs Postnatal Ovarian Follicle Lifespan in Mice1
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چکیده
منابع مشابه
Interleukin-1 deficiency prolongs ovarian lifespan in mice.
Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proinflammatory cytokine IL-1 in the age-related exhaustion of ovarian reserve usi...
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Preterm delivery is the leading cause of neonatal mortality and contributes significantly to infant morbidity. Classical cyclooxygenase (COX) inhibitors, such as indomethacin, which inhibit both COX-1 and COX-2, are effective for delaying premature labor, but their use is limited by serious complications to the fetus and neonate, including adverse effects on the ductus arteriosus (DA). Using is...
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www.landesbioscience.com Cell Cycle 3353 The pool of ovarian primordial follicles is established during embryonic development in humans, or after birth in rodents, and serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. Once the pool of primordial follicles has been exhausted, menopause occurs in women around 50 y old. With modern...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2013
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.113.111070